Application of Vilsmeier Reagents in Cyclization in Recent Years

作者:Qian Xiaoqing*; Zhou Heng; Zhan Xiaoping; Liu Zenglu; Mao Zhenmin
来源:Chinese Journal of Organic Chemistry, 2012, 32(12): 2223-2230.
DOI:10.6023/cjoc201206026

摘要

The Vilsmeier-Hack reaction has historically been a topic of great interest to organic chemists, and it continues to attract considerable attention. The Vilsmeier-Hack reaction provides a facile entry into large numbers of aromatic and heteroaromatic systems. Vilsmeier reagents generated from amides and halides have been found to be very important in organic synthesis. Acylation, chlorination, chloroformylation, aromatization, rearrangement, dehydration and cyclization are the most reactions of Vilsmeier reagents. The application of Vilsmeier reagents in cyclization is introduced.