Novel drug designing rationale against Brugia malayi microfilariae using herbal extracts

作者：Sharma R D; Petare S; Shinde G B; Goswami Kalyan^*; Reddy M V R

来源：Asian Pacific Journal of Tropical Medicine, 2010, 3(11): 846-850.

DOI：10.1016/S1995-7645(10)60204-0

• Herbal extracts
• Polyphenolics
• Apoptosis
• Brugia malayi

Objective: To explore the effect of herbal polyphenolics on filariasis in vitro. Methods: Two herbal extracts, methanolic extracts of roots of Vitex negundo Linn. (Nirgundi) and leaves of Aegle marmelos Juss. (Beal) in different concentrations ranging from 40-80 ng/mL were tested for their antifilarial activity either alone or in combination with diethyl carbonate (DEC) (300 mu g/mL) and/or H(2)O(2) (0.5 mM). Results: Combination of DEC and each extract had significant anti-filarial effect. And fractions of both extracts were not effective as crude herbal extract:. Conclusions: Such unique pharmacodynamics reported in this study might provide new drug development stratagem against filariasis.

• 出版日期2010-11
• 单位河北医科大学