FeOOH-loaded mesoporous silica nanoparticles as a theranostic platform with pH-responsive MRI contrast enhancement and drug release

作者：Huang, Guoming; Liu, Rui; Hu, Yuehua; Li, Shi-Hua; Wu, Ying; Qiu, Yuan; Li, Jingying^*; Yang, Huang-Hao

来源：Science China Chemistry, 2018, 61(7): 806-811.

DOI：10.1007/s11426-017-9217-4

• mesoporous silica nanoparticles
• magnetic resonance imaging
• pH-response
• cancer diagnosis
• cancer therapy

The development of stimuli-responsive theranostic platforms is of great demand for efficient cancer treatment because they can enhance diagnostic specificity and sensitivity. In this work, we report a pH-responsive theranostic nanoplatform based on FeOOH clusters loaded mesoporous silica nanoparticles (Fe@MSNs). The as-synthesized Fe@MSNs possess activatable T (1) magnetic resonance imaging (MRI) performance that can respond to the acidic microenvironment of solid tumor to turn on T (1) singals by releasing paramagnetic Fe3+ ions. The Fe@MSNs are biocompatible without appreciable cytotoxicity. Moreover, the unique mesoporous structure endows the Fe@MSNs with significant advantages to effectively deliver chemotherapeutic drug for inhibiting the growth of solid tumor. We believe that this novel pH-responsive theranostic nanoplatform holds great promise in cancer treatment.

• 出版日期2018-7
• 单位福州大学