All oligosaccharide moieties of the mu chains in the pre-BCR are of the high-mannose type

作者：Haimovich Joseph; Ben Moshe Natalie; Raviv Yasmin; Hollander Nurit^*

来源：Molecular Immunology, 2010, 48(1-3): 351-355.

DOI：10.1016/j.molimm.2010.07.005

• B cell differentiation
• Glycosylation
• B cell receptor
• Pre B cell receptor

Although it is well established that pre-BCR signaling governs proliferation and differentiation during B cell development the components of the pre-BCR that are important for signaling are a matter of controversy It has been suggested that signaling by the mu heavy chains of the pre-BCR induces survival and differentiation of pre-B cells while the lambda 5 part of the pre-BCR is essential for proliferation and clonal expansion However the mechanism by which pre-BCR mu chains initiate differentiation signals is not clear Using two variants of a murine B-lymphocyte cell line that differ only in surface expression of either BCR or pre-BCR we demonstrated that surface mu chains in the pre-BCR are of the high-mannose type only while those in the BCR are of the complex type It

• 出版日期2010-12