MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/beta-catenin pathway and interaction with SNAIL promoter

作者：Gnemmi Viviane^*; Bouillez Audrey; Gaudelot Kelly; Hemon Brigitte; Ringot Belinda; Pottier Nicolas; Glowacki Francois; Villers Arnauld; Vindrieux David; Cauffiez Christelle; Van Seuningen Isabelle; Bernard David; Leroy Xavier; Aubert Sebastien; Perrais Michael

来源：Cancer Letters, 2014, 346(2): 225-236.

DOI：10.1016/j.canlet.2013.12.029

• MUC1
• SNAIL
• Epithelial mesenchymal transition
• Beta catenin
• GO-203

MUC1 is overexpressed in human carcinomas. The transcription factor SNAIL can activate epithelial mesenchymal transition (EMT) in cancer cells. In this study, in renal carcinoma, we demonstrate that (i) MUC1 and SNAIL were overexpressed in human sarcomatoid carcinomas, (ii) SNAIL increased indirectly MUC1 expression, (iii) MUC1 overexpression induced EMT, (iv) MUC1 C-terminal domain (MUC1-C) and p-catenin increased SNAIL transcriptional activity by interaction with its promoter and (v) blocking MUC1-C nuclear localization decreased Wnt/beta-catenin signaling pathway activation and SNAIL expression. Altogether, our findings demonstrate that MUC1 is an actor in EMT and appears as a new therapeutic target.

• 出版日期2014-5-1