Drug interactions: principles and practice

作者：Snyder Ben D^*; Polasek Thomas M; Doogue Matthew P

来源：Australian Prescriber, 2012, 35(3): 85-88.

DOI：10.18773/austprescr.2012.037

• drug interactions
• patient harm
• pharmacodynamics
• pharmacokinetics
• therapeutic index

Drug interactions are an avoidable cause of patient harm. Harm may occur due to either increased drug effect causing toxicity or decreased drug effect leading to therapeutic failure. %26lt;br%26gt;Drug interactions should be considered both in the differential diagnosis of symptoms (for interactions that have already occurred) and when prescription changes are made (for potential interactions). %26lt;br%26gt;Software checkers for drug interactions are widely available, but have limited clinical utility. %26lt;br%26gt;Patient harm from drug interactions can be reduced by: %26lt;br%26gt;. using a personal formulary - using few drugs and knowing them well %26lt;br%26gt;. recognising drugs that are major perpetrators of interactions %26lt;br%26gt;. recognising narrow therapeutic index drugs as vulnerable to interactions %26lt;br%26gt;. applying clinical pharmacology principles.

• 出版日期2012-6