An improved protocol for the preparation of (S)-vinylglycine from (S)-methionine

作者:Kuechenthal Christian H; Migenda Julia; Polednia Magdalena; Maison Wolfgang*
来源:Amino Acids, 2010, 39(2): 443-448.
DOI:10.1007/s00726-009-0460-3

摘要

We present an optimized procedure for the synthesis of (S)-vinylglycine from (S)-methionine. The key step is a solvent free pyrolysis of an intermediate sulfoxide at high temperature. Using our optimized reaction conditions, Cbz-protected vinylglycine was obtained in high yield and with almost no side products. The protocol is scalable, fast and avoids the use of poisonous reagents.