Urethral dilatation: Is there any benefit over cystoscopy and distension? A randomized trial in women with overactive bladder symptoms

作者：Basu Maya^*; Khullar Vik; Duckett Jonathan

来源：Neurourology and Urodynamics, 2014, 33(3): 283-288.

DOI：10.1002/nau.22411

• overactive bladder
• urethral dilatation
• voiding

Aim %26lt;br%26gt;To evaluate the effect of urethral dilatation (UD) on urgency symptoms in women with overactive bladder (OAB) and voiding dysfunction. %26lt;br%26gt;Methods %26lt;br%26gt;Women with OAB symptoms and a maximum flow rate of less than 15 ml/sec on a volume voided of 200 ml were eligible for entry to the trial. Fifty women with OAB symptoms and a maximum flow rate of less than 15 ml/sec on a volume voided of over 200 ml were randomized to undergo UD plus cystoscopy or cystoscopy alone. All subjects underwent filling and voiding cystometry pre-operatively and at 6 weeks%26apos; post-operatively. Subjective outcomes were assessed using the Urgency Perception Scale (UPS) and King%26apos;s Health Questionnaire at baseline, 6 weeks and 6 months. The primary outcome measure was cure of urgency, defined using the UPS. %26lt;br%26gt;Results %26lt;br%26gt;Urgency was cured in 10/22 (45%) patients in the UD group and 5/28 (18%) in the non-UD group at 6 weeks (Odds ratio 3.8, 95% confidence interval 1.1-13.8, P = 0.03). Cystometric flow data were available for all patients pre- and post-UD. UD was associated with a significant increase in the flow rate centile from 1.66 to 8.54 (P = 0.01). At 6 months there was no benefit from UD with 4/22 in the UD group cured of urgency and 4/28 in the non-UD group cured (Odds ratio 1.3, 95% confidence interval 0.3-6.1, P = 0.50). %26lt;br%26gt;Conclusion %26lt;br%26gt;UD confers a significant short-term benefit in cure of urgency over cystoscopy alone, but there is no significant benefit in symptom relief in the long term. Neurourol. Urodynam. 33:283-288, 2014.

• 出版日期2014-3