Mechanisms of Prostate Atrophy after LHRH Antagonist Cetrorelix Injection: An Experimental Study in a Rat Model of Benign Prostatic Hyperplasia

作者：Yang, Dong; Hou, Teng; Yang, Xiong; Ma, Yan; Wang, Longwang; Li, Bing^*

来源：Journal of Huazhong University of Science and Technology-Medical Sciences, 2012, 32(3): 389-395.

DOI：10.1007/s11596-012-0067-x

• benign prostatic hyperplasia
• LHRH
• transforming growth factor-beta

In the present study, we investigated the roles of TGF-beta signaling pathway in a rat benign prostatic hyperplasia (BPH) model treated with cetrorelix. TGF-beta 1 and c-Myc expression were measured by qRT-PCR and Western blotting in the proximal and distal region of ventral prostatic lobes, respectively. We observed that treatment with cetrorelix led to a significant reduction of ventral prostate weight in a dose-dependent manner. In the proximal region, after cetrorelix treatment, the expression of TGF-beta 1 was dramatically increased (P<0.05), while the expression of c-Myc was significantly decreased (P<0.05). In comparison with the control group, the cetrorelix groups had more TUNEL-positive cells. Our findings strongly suggest that the TGF-beta signaling pathway may be one of the major causes responsible for prostate volume reduction in BPH rats after cetrorelix treatment.

• 出版日期2012-6
• 单位华中科技大学; 暨南大学