Altered spontaneous brain activity pattern in cognitively normal young adults carrying mutations of APP, presenilin-1/2 and APOE ε4

作者：Zheng, Li Juan; Su, Yun Yan; Wang, Yun Fei; Zhong, Jianhui; Liang, Xue; Zheng, Gang; Lu, Guang Ming; Zhang, Long Jiang^*

来源：European Journal of Radiology, 2017, 95: 18-23.

DOI：10.1016/j.ejrad.2017.07.006

• Regional homogeneity
• Apolipoprotein E
• Amyloid precursor protein
• Presenilin 1/2
• Alzheimer's disease

Objective: To explore genetic effects of amyloid precursor protein (APP), presenilin-1/2 and apolipoprotein E (APOE) s4 on brain structural and functional alterations in cognitively normal young adults. @@@ Materials and methods: Eighty healthy adults (mean age 24.0 +/- 2.5 years; n = 18, APP/presenilin-1/2 group; n = 31, APOE epsilon 4 group; n = 31, control group [without above-mentioned gene mutation]) underwent high resolution Tl-weighted 3D anatomical imaging, resting-state functional MR imaging and neuropsychological assessments. We used voxel-based morphometry and regional homogeneity (ReHo) algorithms to investigate brain structural and functional changes among three groups, and performed correlation analyses between the brain regions with statistically significant difference and neuropsychological results. @@@ Results: No brain structural changes were found, however, ReHo values were increased in right parietal-frontal lobes in APOE epsilon 4 group, and decreased in the left middle temporal gyrus in APP/presenilin-1/2 group compared with controls (all P < 0.05). Compared with APOE epsilon 4 group, decreased ReHo values of bilateral temporal lobes were shown in APP/presenilin-1/2 group (P < 0.05). ReHo values of right superior frontal gyrus in APOE s4 group positively correlated with neuropsychological tests scores(P < 0.05). @@@ Conclusion: Cognitively normal young adults carrying APOE s4 or APP/presenilin-1/2 had different spontaneous brain activity patterns without cerebral structural differences.

• 出版日期2017-10
• 单位浙江大学; 中国民航大学; 南京大学; 南京航空航天大学