科研之友
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摘要
AimsTo examine the effects of longitudinal changes in fat mass or lean body mass on risk of Type 2 diabetes in Korean adults. %26lt;br%26gt;MethodsParticipants included 18 687 Korean adults (aged 20-79years) who underwent routine medical check-ups in 2007-2008 and again in 2011-2012 with a mean (range) of 4.3 (3.0-5.7) years interval. Total fat, fat-free, and soft fat-free masses were determined using bioelectrical impedance. %26lt;br%26gt;ResultsA total of 692 subjects (3.7%) developed Type 2 diabetes during follow-up. Those who developed diabetes had a greater increase in percent body fat (2.93.0 vs 2.63.2 percentage points, P=0.043), as well as greater decreases in percent fat-free mass (-3.03.3 vs -2.73.3 percentage points, P=0.008) and percent soft fat-free mass (-2.83.1 vs -2.4 +/- 3.1 percentage points, P=0.003) compared with those who did not develop diabetes. In multiple logistic regression analysis, an increase in total fat mass of %26gt; 10% was associated with an increased odds ratio for diabetes (1.29, 1.05-1.60), and a decreased total fat mass was associated with lower odds ratio (0.75, 0.58-0.96). A loss of total fat-free mass of %26gt; 5% (odds ratio 1.08, 0.90-1.30) or an increase in total fat-free mass (odds ratio 0.96, 0.71-1.28) was not significantly associated with the risk of diabetes after adjustments for baseline waist circumference and glucose levels. %26lt;br%26gt;ConclusionsThese results show that changes in total body fat mass, but not lean body mass, are associated with development of Type 2 diabetes, independently of baseline measures of general or central obesity.
- 出版日期2014-11
