Development of a three-dimensional surface imaging system for melanocytic skin lesion evaluation

作者：Tosca Androniki^*; Kokolakis Athanasios; Lasithiotakis Konstantinos; Zacharopoulos Athanasios; Zabulis Xenophon; Marnelakis Ioannis; Ripoll Jorge; Stephanidis Constantine

来源：Journal of Biomedical Optics, 2013, 18(1): 016009.

DOI：10.1117/1.JBO.18.1.016009

• surface morphology
• stereoscopic imaging device
• photorealistic 3D reconstruction
• melanoma
• melanocytic nevi
• melanocytic skin lesions
• 3D imaging

Even though surface morphology is always taken into account when assessing clinically pigmented skin lesions, it is not captured by most modern imaging systems using digital imaging. Our aim is to develop a novel three-dimensional (3D) imaging technique to record detailed information of the surface anatomy of melanocytic lesions that will enable improved classification through digital imaging. The apparatus consists of three high-resolution cameras, a light source, and accompanying software. Volume measurements of specific phantoms using volumetric tubes render slightly lower values than those obtained by our 3D imaging system (mean% +/- SD, 3.8% +/- 0.98, P %26lt; 0.05). To examine the reproducibility of the method, sequential imaging of melanocytic lesions is carried out. The mean% +/- SD differences of area, major axis length, volume, and maximum height are 2.1% +/- 1.1, 0.9% +/- 0.8, 3.8% +/- 2.9, and 2.5% +/- 3.5, respectively. Thirty melanocytic lesions are assessed, including common and dysplastic nevi and melanomas. There is a significant difference between nevi and melanomas in terms of variance in height and boundary asymmetry (P %26lt; 0.001). Moreover, dysplastic nevi have significantly higher variances in pigment density values than common nevi (P %26lt; 0.001). Preliminary data suggest that our instrument has great potential in the evaluation of the melanocytic lesions. However, these findings should be confirmed in larger-scale studies. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.18.1.016009]

• 出版日期2013-1