A simple one-step extraction method for the determination of organophosphorus pesticides in shuanghuanglian and antivirus oral liquids by gas chromatography-tandem mass spectrometry

作者：Wang, Bin; Zhong, Yao; Mao, Xuejin^*; Wan, Yiqun

来源：Analytical Methods, 2015, 7(16): 6821-6827.

DOI：10.1039/c5ay01519g

• FLAME PHOTOMETRIC DETECTION
• SOLID-PHASE MICROEXTRACTION
• TRADITIONAL CHINESE MEDICINE
• MULTIRESIDUE DETERMINATION
• ORGANOCHLORINE PESTICIDES
• SOLVENT-EXTRACTION
• GC-MS
• RESIDUES
• OPTIMIZATION
• WINES

A new multi-residue method was proposed for the determination of 11 organophosphorus pesticides (OPPs) in Traditional Chinese medicinal preparation oral liquids. The method was based on a simple one-step extraction procedure without further clean-up step. The analytes were extracted by a solvent mixture of acetone and n-hexane, and the experimental parameters such as the ratio of acetone : n-hexane (v/v), the volume of extraction solvent and the extraction time were optimized via orthogonal array experimental design (OAD). All of the pesticides were successfully identified and quantified by gas chromatography-tandem mass spectrometry (GC-MS/MS). The linearity of calibration curves is excellent for matrix-matched standards and yields the coefficients of determination (R-2) > 0.9997 for the target analytes. Low limits of quantification (10 mu g L-1) were achieved. Under optimized conditions, the average recoveries for most pesticides (spiked at 10, 20, and 50 mu g L-1) range from 70% to 120%, and RSDs are less than 13.3%. This satisfactory method has been established for the first time for the determination of OPPs in Traditional Chinese medicinal preparation oral liquids.

• 出版日期2015
• 单位南昌大学; 食品科学与技术国家重点实验室