The Hsp90 inhibitor 17-DMAG decreases infection of porcine circovirus type 2 in mice

作者：Liu, Jie; You, Jinwei; Zhang, Xuliang; Ma, Chang; Dong, Min; Chen, Li; Jiang, Ping; Yun, Shifeng^*

来源：Microbial Pathogenesis, 2017, 109: 248-252.

DOI：10.1016/j.micpath.2017.06.007

• Antiviral
• BALB/c mice
• Porcine circovirus type 2
• 17-DMAG

Although several factors affecting porcine circovirus type 2 (PCV2) infection have been reported, their precise roles are far from clear. The aim of this study was to determine whether 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), an inhibitor of Hsp90, could significantly affect PCV2 infection and immune responses in BALB/c mice. Intraperitoneal injection of 17-DMAG significantly reduced viral loads in the blood and tissues of mice infected with PCV2, compared with control groups. The 17-DMAG treatment decreased serum interleukin (IL)-10 and tumor necrosis factor(TNF)-alpha levels, but it did not have a significant effect on the IL-1 beta level. These data demonstrate that 17-DMAG is highly effective in suppressing PCV2 replication in BALB/c mice, indicating that it has potential value as an antiviral drug against PCV2 infection.

• 出版日期2017-8
• 单位南京农业大学