Massive fatal pulmonary haemorrhage during bevacizumab treatment following microwave ablation therapy for oligometastatic lung metastasis from rectal cancer

作者：Prasanna Thiru; Briggs Greg; Jain Sanjiv; Yip Desmond^*

来源：Interactive Cardiovascular and Thoracic Surgery, 2018, 26(3): 514-515.

DOI：10.1093/icvts/ivx342

• Haemorrhage
• Bronchial fistula
• Bevacizumab
• Wound healing

Although thoracic ablative therapies are generally safe procedures, fatal complications can occur. Bevacizumab is a standard-of-care treatment along with chemotherapy for metastatic colorectal cancer. Although uncommon, unpredictable serious adverse events can occur secondary to bevacizumab. We report a case of fatal intrapulmonary haemorrhage as a result of arteriopulmonary fistula in a patient after microwave ablation of pulmonary colorectal cancer metastasis while on bevacizumab. Antiangiogenetic properties of bevacizumab are associated with delayed wound healing, which might have been a crucial factor in the development of arteriopulmonary fistula and haemorrhage.

• 出版日期2018-3