Design and synthesis of a chiral seven-membered ring guanidine organocatalyst applied to asymmetric vinylogous aldol reactions

作者：Mirabdolbaghi Roya; Hassan Mohamed; Dudding Travis^*

来源：Tetrahedron: Asymmetry , 2015, 26(10-11): 560-566.

DOI：10.1016/j.tetasy.2015.04.001

A computationally based design and synthesis of a point chiral seven-membered ring guanidine organocatalyst is reported. The application of this catalyst in asymmetric vinylogous aldol reactions, to form optically active gamma-butenolide products with dr's and er's up to 90:10 and 97:3 is described.

• 出版日期2015-5-31