A convection-driven long-range linear gradient generator with dynamic control

作者:Wang Hao; Chen Chia Hung*; Xiang Zhuolin; Wang Ming; Lee Chengkuo
来源:Lab on a Chip, 2015, 15(6): 1445-1450.
DOI:10.1039/c4lc01451k

摘要

We developed a novel gradient generator to achieve long range and linear chemical gradients with a dynamic control function. The length of the gradient can be on the centimetre scale. The gradient profile can be tuned by changing the flow rates. The device can work in both high flow rate regimes with large shear stress and low flow rate regimes with minimum shear stress. The drug screening function was demonstrated by the viability test of PC-9 cancer cells.

  • 出版日期2015