An update on nuclear calcium signalling

作者：Bootman Martin D; Fearnley Claire; Smyrnias Ioannis; MacDonald Fraser; Roderick H Llewelyn^*

来源：Journal of Cell Science, 2009, 122(14): 2337-2350.

DOI：10.1242/jcs.028100

• Calcium
• Gene transcription
• InsP(3)
• Nucleus
• Paclitaxel
• Ryanodine
• Signalling
• Spindle checkpoint
• Taxol

Over the past 15 years or so, numerous studies have sought to characterise how nuclear calcium (Ca(2+)) signals are generated and reversed, and to understand how events that occur in the nucleoplasm influence cellular Ca(2+) activity, and vice versa. In this Commentary, we describe mechanisms of nuclear Ca(2+) signalling and discuss what is known about the origin and physiological significance of nuclear Ca(2+) transients. In particular, we focus on the idea that the nucleus has an autonomous Ca(2+) signalling system that can generate its own Ca(2+) transients that modulate processes such as gene transcription. We also discuss the role of nuclear pores and the nuclear envelope in controlling ion flux into the nucleoplasm.

• 出版日期2009-7-15