A Novel Ultra-porous Titanium Dioxide Ceramic with Excellent Biocompatibility

作者：Sabetrasekh Roya; Tiainen Hanna; Lyngstadaas S Petter; Reseland Janne; Haugen Havard^*

来源：Journal of Biomaterials Applications, 2011, 25(6): 559-580.

DOI：10.1177/0885328209354925

• bone graft substitute
• titanium dioxide
• microCT
• human primary mesenchymal stem cells
• porosity
• cytotoxicity
• bone graft

The current study compares biocompatibility, cell growth and morphology, pore diameter distribution, and interconnectivity of a novel titanium dioxide (TiO2) bone graft substitute granules with three different commercially available bone graft granules Natix (R), Straumann (R) BoneCeramic, and Bio-Oss (R). Human primary mesenchymal stem cells were cultured on the bone graft substitutes and cell viability and proliferation were evaluated after 1 and 3 days. The microstructural properties of the bone graft substitutes were evaluated by scanning electron microscopy, micro-computed tomography analysis, and mechanical testing. The cell viability and proliferation, porosity, interconnectivity, open pore size, and surface area-to-volume ratio of TiO2 granules were significantly higher than commercial bone granules (Bio-Oss (R) and Straumann (R) BoneCeramic).

• 出版日期2011-2