科研之友
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摘要
Searching new targets for anti-inflammatory drug design, agents with the isoindole skeleton were focused on the basis of preliminary studies of NSAIDs as COX-1 and/or COX-2 enzyme inhibitors. Thus several novel N-substituted isoindoline derivatives as possible biologically active compounds were prepared as analogues of Indoprofen (1) starting from cis-2-[(4-methylphenyl)carbonyl]cyclohexanecarboxylic acid (3) by treatment with primary arylamines.
- 出版日期2013
