A Chemo-Enzymatic Expeditious Route to Racemic Dihexanoyl (2R*,3R*,4R*)-Dehydroxymethylepoxyquinomycin (DHMEQ), the Precursor for Lipase-Catalyzed Synthesis of the Potent Nuclear Factor-kappa B Inhibitor, (2S,3S,4S)-DHMEQ

作者：Kobayashi Ryohei; Hanaya Kengo; Shoji Mitsuru; Umezawa Kazuo; Sugai Takeshi^*

来源：Chemical & Pharmaceutical Bulletin, 2012, 60(9): 1220-1223.

• dehydroxymethylepoxyquinomycin
• process chemistry
• hydroquinone
• oxidation
• benzoquinone
• epoxidation

In order to synthesize the potent nuclear factor (NF)-kappa B inhibitor, (2S,3S,4S)-dehydroxymethylepoxyquinomycin (DHMEQ), in a large scale, a new route for its corresponding racemic precursor, dihexanoyl (2R*,3R*,4R*)-DHMEQ, was developed. By employing both hydroquinone and benzoquinone intermediates, the total yield, reproducibility, and synthetic steps were improved and the synthetic cost was reduced.

• 出版日期2012-9