New treatments for gout

作者：Mapa Janet B; Pillinger Michael H^*

来源：Current Opinion in Investigational Drugs, 2010, 11(5): 499-506.

• Allopurinol
• allopurinol hypersensitivity syndrome
• caspase 1 inhibitor
• febuxostat
• gout
• IL-1 beta inhibitor
• monosodium urate crystal
• melanocyte-stimulating hormone receptor agonist
• PEGylated uricase
• URAT1 inhibitor

Gout is a commonly occurring medical condition that can lead to significant morbidity. Therapies available for the treatment of both acute and chronic gouty arthritis have not changed significantly since the 1960s. Although these treatments are well established, they are often contraindicated in the presence of various different comorbidities, including diabetes, renal insufficiency, hypertension and gastrointestinal disease, all of which can occur frequently in patients with gout. Therefore, new treatments are needed. This review describes recent advances in therapeutics for gout, including drugs designed to reduce levels of urate and to inhibit acute or chronic inflammation. While some of these strategies are currently available, others are undergoing regulatory evaluation or are at earlier stages of development.

• 出版日期2010-5