Acid-catalyzed tandem reaction for the synthesis of pyridine derivatives via C=C/C(sp(3))-N bond cleavage of enones and primary amines

作者：Mao, Zhong-Yuan; Liao, Xiao-Yun; Wang, Heng-Shan; Wang, Chun-Gu; Huang, Ke-Bin^*; Pan, Ying-Ming^*

来源：RSC Advances, 2017, 7(22): 13123-13129.

DOI：10.1039/c7ra00780a

• ONE-POT SYNTHESIS
• C-H ACTIVATION
• SUBSTITUTED PYRIDINES
• POLYSUBSTITUTED PYRIDINES
• FUNCTIONALIZED PYRIDINES
• REGIOSELECTIVE SYNTHESIS
• 2+2+2 CYCLOADDITION
• TERMINAL ALKYNES
• OXIME ESTERS
• NITRILE

A one-pot acid-catalyzed tandem reaction has been developed without any metallic reagents or extra oxidants. This reaction involves a C=C bond cleavage of enones via a "masked" reverse Aldol reaction, and C(sp(3))-N bond cleavage of primary amines to provide nitrogen sources for the assembly of pyridine derivatives in high yields with excellent functional group tolerance.

• 出版日期2017
• 单位广西师范大学