Amenorrhea as a rare drug-related adverse event associated with everolimus for pancreatic neuroendocrine tumors

作者：Kawaguchi Yoshiaki^*; Maruno Atsuko; Kawashima Yohei; Ito Hiroyuki; Ogawa Masami; Mine Tetsuya

来源：World Journal of Gastroenterology, 2014, 20(42): 15920-15924.

DOI：10.3748/wjg.v20.i42.15920

• Amenorrhea
• Everolimus
• Neuroendocrine tumor
• Pancreas
• Adverse event

The patient was an asymptomatic 43-year-old woman. Abdominal ultrasonography and enhanced computed tomography showed a tumor lesion accompanied by multiple cystic changes in the liver and the pancreatic tail. Endoscopic ultrasound-fine needle aspiration was performed on the pancreatic tumor lesion and revealed pancreatic neuroendocrine tumor (PNET). As it was unresectable due to multiple liver metastases, the decision was made to initiate treatment with everolimus and transcatheter arterial chemoembolization. The patient ceased menstruating after the start of everolimus administration. When the administration was discontinued due to interstitial lung disease, menstruation resumed, but then again stopped with everolimus resumption. An association between everolimus and amenorrhea was highly suspected. Amenorrhea occurred as a rare adverse event of everolimus. As the younger women might be included in PNETs patients, we should put this adverse event into consideration.

• 出版日期2014-11-14