Association of MCP-1-2518A/G and-362G/C variants and tuberculosis susceptibility: A meta-analysis

作者：Gong Tian; Yang Mei; Qi Ling; Shen Min^*; Du Yukai

来源：Infection, Genetics and Evolution, 2013, 20: 1-7.

DOI：10.1016/j.meegid.2013.08.001

• MCP-1
• Single nucleotide polymorphism
• Tuberculosis
• Susceptibility
• Meta-analysis

A number of studies have found that the -2518A/G and -362G/C polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene are implicated in the susceptibility to tuberculosis. However, the results are inconsistent. To investigate the relationship between -2518A/G and -362G/C polymorphisms in MCP-1 gene and the susceptibility of tuberculosis, a systematic literature search for relevant articles published up to January, 2013 was conducted in the databases of PubMed, Elsevier, Web of Science, Wanfang and CNKI. A total number of twenty-two case-control studies that included 9365 cases and 10149 controls on two single-nucleotide polymorphisms (SNPs): -2518A/G and -362G/C, were identified. The results indicated that the G allele of -2518A/G polymorphism was associated with increased risk of tuberculosis (GG vs. AA + AG: OR 1.455, 95% CI 1.092-1.937, P = 0.01). In the subgroup analysis by ethnicity, significant elevated risks were found in Asians and Americans, but not in Africans. The C allele of -362G/C polymorphism was associated with resistance to tuberculosis (CC vs. GG + GC: OR 0.837, 95% CI 0.772-0.987, P = 0.03). This meta-analysis suggests that the G allele of -2518A/G polymorphism is a risk factor for tuberculosis in Asians and Americans, while not in Africans. It further indicates that C allele of -362G/C polymorphism is a protective factor for tuberculosis.

• 出版日期2013-12
• 单位华中科技大学