Annular erythema associated with Sjogren's syndrome: review of the literature on the management and clinical analysis of skin lesions

作者：Katayama Ichiro^*; Kotobuki Yorihisa; Kiyohara Eiji; Murota Hiroyuki

来源：Modern Rheumatology, 2010, 20(2): 123-129.

DOI：10.1007/s10165-009-0257-y

• Annular erythema
• Management
• SCLE
• Sjogren's syndrome
• Steroids

Annular erythema has been recognized to be a specific, cutaneous manifestation associated with Sjogren's syndrome. Based on a search of the literature up to 2007, annular erythema with Sjogren's syndrome (AESS) preferentially occurs in Asian but not in Western populations. However, the precise clinical course and standard regimen for the management of AESS have remained obscure, primarily because of its rare occurrence in Western populations and the fact that most Asian cases are isolated reports. In this study, 28 cases of AESS from our department and 92 cases distilled from the literature were enrolled in a retrospective study to evaluate the clinical characteristics and most desirable management of this skin manifestation in Sjogren's syndrome. We found that 75% of all cases with AESS were positive for both anti-SSA and anti-SSB antibodies. Multiple therapeutic options are available to treat AESS, including oral steroids. Several anti-malaria drugs or tacrolimus ointment have also been reported to be effective against AESS. AESS is a distinct clinical entity, and a small dose of prednisolone (approx. 10 mg) is sufficient to control diseases activity, except in some cases with systemic manifestations, and this treatment has a more rapid clinical effect than topical steroids.

• 出版日期2010-4