Development of a highly sensitive electrochemiluminescence sophoridine sensor using Ru(bpy)32+ integrated carbon quantum dots - polyvinyl alcohol composite film

作者：Liu, Zhimin^*; Zhang, Xing; Cui, Lin; Wang, Kang; Zhan, Haijun

来源：Sensors and Actuators B: Chemical , 2017, 248: 402-410.

DOI：10.1016/j.snb.2017.03.115

• Electrochemiluminescence
• Sensor
• Carbon quantum dots
• Sophoridine

A facile electrochemiluminescence (ECL) sensing platform for the sensitive analysis of sophoridine was constructed using Ru(bpy)(3)(2+)/carbon quantum dots - polyvinyl alcohol composite film as modifier. The carbon quantum dots (CQDs) which have the ability to enhance the ECL intensity were synthesized through a simple hydrothermal method. As Ru(bpy)(3)(2+) was entrapped in the polyvinyl alcohol (PVA), it was beneficial to immobilize Ru(bpy)(3)(2+) efficiently on the GCE surface, and therefore a stable ECL signal could be obtained. In addition, the ECL response on the Ru(bpy)(3)(2+)/CQDs/PVA composite system was greatly enhanced by sophoridine. Single-factor was applied to optimize the measurement conditions. The fabricated sophoridine sensor exhibited a well-proportional correlation between ECL intensity and the logarithm of sophoridine concentration in the range of 1.0 x 10(-10)-1.0 x 10(-5) M, and the detection limit was 5.0 10(-11) M (S/N = 3). Moreover, the detection of sophoridine in blood serum was successfully accomplished and a desirable result by using the ECL sensing system was achieved, which indicated that the fabricated ECL sensor has potential value in sophoridine monitoring in practical samples.

• 出版日期2017-9
• 单位河南工业大学