A Stereoselective Reductive Hosomi-Sakurai Reaction

作者:Bauer Adriano; Maulide Nuno*
来源:Organic Letters, 2018, 20(5): 1461-1464.
DOI:10.1021/acs.orglett.8b00276

摘要

A novel reductive variant of the classical Hosomi-Sakurai reaction is reported. This transformation hinges on a redox-neutral, stereoselective internal reduction event under mild conditions. This operationally simple reaction relies on readily available starting materials and leads to useful products in diastereoselectivities of up to 7:1. The versatility of this new method is demonstrated through the stereoselective one-step synthesis of an AChE inhibitor.

  • 出版日期2018-3-2