Anti-Mullerian hormone levels in salpingectomized compared with nonsalpingectomized women with tubal factor infertility and women with unexplained infertility

作者：Grynnerup Anna G A; Lindhard Anette; Sorensen Steen^*

来源：Acta Obstetricia et Gynecologica Scandinavica, 2013, 92(11): 1297-1303.

DOI：10.1111/aogs.12234

• Anti-Mullerian hormone
• salpingectomy
• ovarian reserve
• fertilization in vitro
• sensitivity and specificity

ObjectiveTo investigate the consequence of salpingectomy on ovarian reserve by measuring anti-Mullerian hormone (AMH) levels before in vitro fertilization (IVF) treatment in salpingectomized women compared with nonsalpingectomized women with tubal factor infertility, women with unexplained infertility and fertile control women, and to evaluate whether AMH levels could predict IVF outcome.
DesignCross-sectional study extended from a previous prospective study.
SettingFour university fertility clinics.
PatientsSeventy-one women with infertility and 21 fertile controls.
InterventionsBlood sampling and IVF and embryo transfer in the following cycle.
Main outcome measureSerum AMH levels and oocytes retrieved.
ResultsAnti-Mullerian hormone levels were significantly lower in the salpingectomy infertility group (median 16.1, range 5.2-54pmol/L) compared with the nonsalpingectomy tubal factor infertility group (median 23.4, range 3.5-50pmol/L; p=0.04). In all groups, AMH levels correlated positively with the number of oocytes retrieved. AMH predicted poor response (five or fewer oocytes) with a sensitivity and specificity of 90% and 70%, at a 19pmol/L cut-off value.
ConclusionSerum AMH levels were lower in salpingectomized women compared with women with tubal factor infertility and preserved Fallopian tubes, indicating that ovarian reserve might be affected by tubal surgery. Furthermore, serum AMH levels could predict a poor oocyte response (five or fewer oocytes) in the study group of infertile women.

• 出版日期2013-11