A convenient new route to enantiopure 3-hydroxy-5-oxo esters and 5,6-dihydropyran-2-ones: intricacies of the trithioorthoester protecting group

作者：Grange Rebecca L; Williams Craig M^*

来源：Tetrahedron Letters, 2010, 51(8): 1158-1160.

DOI：10.1016/j.tetlet.2009.12.058

3-Hydroxy-5-oxo esters are useful precursors to biologically active compounds. An expedient three-step synthesis of 3-hydroxy-5-oxo esters based on dithiane anion chemistry is presented along with the transformation of the 3-hydroxy-5-oxo esters into 5.6-dihydropyran-2-ones.

• 出版日期2010-2-24