Differential Outcome of IL-2/Anti-IL-2 Complex Therapy on Effector and Memory CD8(+) T Cells following Vaccination with an Adenoviral Vector Encoding EBV Epitopes

作者：Smith Corey; Martinez Michelle; Peet Jesse; Khanna Rajiv^*

来源：The Journal of Immunology, 2011, 186(10): 5784-5790.

DOI：10.4049/jimmunol.1003394

IL-2/anti-IL-2 complex-based therapy has been proposed as a potential adjunct therapeutic tool to enhance in vivo efficacy of T cell-based immunotherapeutic strategies for chronic viral infections and human cancers. In this study, we demonstrate that IL-2 complex therapy can have discerning effects on CD8(+) T cells depending on their stage of differentiation. To delineate the underlying mechanism for these opposing effects on CD8(+) T cells, we examined the effects of IL-2 therapy during early priming, effector, and memory phases of T cell responses generated following immunization with an adenoviral vector encoding multiple EBV CD8(+) epitopes. IL-2 complex treatment during the early priming phase, which coincided with low levels of IL-2R beta (CD122) and higher levels of IL-2R alpha (CD25) on CD8(+) T cells, did not induce the expansion of effector T cells. In contrast, IL-2 complex treatment following the establishment of memory enhanced the expansion of Ag-specific T cells. Additionally, central memory T cells preferentially expanded following treatment at the expense of effector memory T cell populations. These studies demonstrate how differentiation status of the responding CD8(+) T cells impacts on their responsiveness to IL-2 complexes and highlight that timing of treatment should be considered before implementing this therapy in a clinical setting. The Journal of Immunology, 2011, 186: 5784-5790.

• 出版日期2011-5-15
• 单位河北医科大学