MicroRNAs in rheumatoid arthritis

作者：Ceribelli Angela; Nahid Md A; Satoh Minoru; Chan Edward K L^*

来源：FEBS Letters, 2011, 585(23): 3667-3674.

DOI：10.1016/j.febslet.2011.05.020

• Autoimmunity
• Innate immunity
• Rheumatoid arthritis
• microRNA
• miR-146a

Rheumatoid arthritis (RA) is a chronic and severe autoimmune disease that affects joint tissues, bone, and cartilage. However, the pathogenesis of RA is still unclear. Autoantibodies such as rheumatoid factor and anti-cyclic citrullinated peptide are useful tools for early diagnosis, monitoring disease activity, and predicting prognosis. Recently, many groups have focused their attention on the role of microRNAs in the pathogenesis of RA, as well as a potential biomarker to monitor RA. In fact, the expression of some microRNAs, such as miR-146a, is upregulated in different cell types and tissues in RA patients. MicroRNAs in RA could also be considered as possible future targets for new therapeutic approaches.

• 出版日期2011-12-1