Association between IL-4-589C > T polymorphism and colorectal cancer risk

作者：Li, Qiang^*; Wang, Qian; Xu, Xiaoyan; Ren, Songtao; Wang, Li

来源：Tumor Biology, 2014, 35(3): 2675-2679.

DOI：10.1007/s13277-013-1352-4

• Colorectal cancer
• Interleukin-4
• Meta-analysis
• Risk

In order to make a comprehensive assessment of the potential association between interleukin-4 (IL-4) -589C > T and colorectal cancer (CRC) susceptibility, we conducted a meta-analysis of six epidemiological studies, which included 1,317 CRC patients and 1,659 controls. The data showed that IL-4 -589C > T was not associated with increased CRC risk in the overall population. In the subgroup analysis of IL-4 -589C > T, the results did not change when the analyses were restricted to race. Based on this meta-analysis, we conclude that IL-4 -589C > T may be not a risk factor for CRC development. Further research is needed to assess possible gene-gene or gene-environment-lifestyle interactions on CRC.

• 出版日期2014-3
• 单位聊城市人民医院