Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine

作者：Lon Chanthap^*; Spring Michele; Sok Somethy; Chann Soklyda; Bun Rathvichet; Ittiverakul Mali; Buathong Nillawan; Thay Khengheng; Kong Nareth; You Yom; Kuntawunginn Worachet; Lanteri Charlotte A; Saunders David L

来源：Malaria Journal, 2014, 13(1): 96.

DOI：10.1186/1475-2875-13-96

• Malaria
• Plasmodium falciparum
• Cambodia
• Blackwater fever
• Dihydroartemisinin-piperaquine

The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine, mefloquine and halofantrine. The potential for drugs containing artemisinins, chloroquine or piperaquine to cause oxidant haemolysis is believed to be much lower, particularly during treatment of uncomplicated malaria. Here is an unusual case of BWF, which developed on day 2 of treatment for uncomplicated Plasmodium falciparum infection with dihydroartemisinin-piperaquine (DHA-PIP) with documented evidence of concomitant seropositivity for Chikungunya infection.

• 出版日期2014-3-14
• 单位河北医科大学