Association between interleukin-4R and TGF-beta 1 gene polymorphisms and the risk of colorectal cancer in a Korean population

作者：Lee Y S; Choi H B; Lee I K; Kim T G; Oh S T^*

来源：Colorectal Disease, 2010, 12(12): 1208-1212.

DOI：10.1111/j.1463-1318.2009.02080.x

• Colorectal cancer
• polymorphisms
• interleukin-4R
• transforming growth factor-beta 1

Aim Colorectal cancer is associated with inflammatory bowel disease. The mechanisms of how different genetic make-ups of cytokines might influence the individual susceptibility to develop particular types of tumours are still unknown. The authors analysed the association between genetic polymorphisms in cytokine/cytokine receptor genes and the risk of colorectal cancer in a Korean population.
Method The authors assessed polymorphisms of the interleukin: IL-1, IL-1R, IL-2, IL-4, IL-4R, IL-10, transforming growth factor (TGF)-beta 1, IFN-gamma genes in Korean patients with colorectal cancer (n = 170) and in a normal healthy control group (n = 130) to investigate the association between theses cytokine gene polymorphisms and the risk of colorectal cancer.
Results The IL-4R 1902*T allele was found to be associated with an increased risk of colon cancer (P < 0.01, OR = 2.0) and rectal cancer (P < 0.05, OR = 1.8). The IL-4R 1902*C allele was associated with a decreased risk of both colon cancer (P < 0.01, OR = 0.51) and rectal cancer (P < 0.05, OR = 0.5). The TFG-beta 1 10*T allele was found to be associated with an increased risk of colon cancer (P < 0.00, OR = 2.3) and the TFG-beta 1 10*C allele with a decreased risk of colon cancer (P < 0.00, OR = 0.43).
Conclusion These results suggest that the genetic polymorphisms of IL-4R and TGF-beta 1 are associated with the risk of colorectal cancer in a Korean population.

• 出版日期2010-12