A 'click chemistry' approach to the efficient synthesis of modified nucleosides and oligonucleotides for PET imaging

作者：James Damien; Escudier Jean Marc; Amigues Eric; Schulz Juergen; Vitry Christiane; Bordenave Thomas; Szlosek Pinaud Magali^*; Fouquet Eric

来源：Tetrahedron Letters, 2010, 51(8): 1230-1232.

DOI：10.1016/j.tetlet.2009.12.120

Different thymidine derivatives bearing either an iodoaryl moiety at the 5' position or a dialkylsilyl group at the 3' position have been efficiently synthesized as precursors for carbon-11 or fluorine-18 labeling, respectively. Furthermore, iodoarylated thymidine derivatives have been incorporated into oligonucleotides giving an original way to label them with carbon-11.

• 出版日期2010-2-24