Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus

作者：Lee Dae Young; Noh Hyung Jun; Choi Jehun; Lee Kyeong Hee; Lee Min Ho; Lee Ji Hyun; Hong Yoonpyo; Lee Seung Eun; Kim Seung Yu; Kim Geum Soog^*

来源：Molecules, 2013, 18(4): 3725-3732.

DOI：10.3390/molecules18043725

• Astragalus membranaceus
• cycloartane-type triterpene
• agroastragaloside V
• nitric oxide

A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-beta-(2'-O-acetyl)-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-(24S)-3 beta,6 alpha,24 alpha,25-tetrahydroxy-9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (H-1, C-13, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

• 出版日期2013-4