Cooperative Binding of Ferrocenylnaphthalene Diimide Carrying beta-Cyclodextrin Converts Double-Stranded DNA to a Rod-Like Structure

作者：Sato Shinobu; Umeda Yuta; Fujii Satoshi; Takenaka Shigeori^*

来源：Bioconjugate Chemistry, 2015, 26(3): 379-382.

DOI：10.1021/bc500535n

Ferrocenylnaphthalene diimide carrying beta-cyclodextrin (beta-CD), 1, intercalated into double-stranded DNA with a binding affinity of K = (6.6 +/- 0.8) x 10(4) M-1 and a binding site size of n = 4, with a high positive cooperative parameter of omega = 14. beta-CD and ferrocene moieties of the compound contributed to the formation of the intermolecular inclusion complex on DNA. Binding of 1 resulted in conversion of the DNA duplex to a rod-like form, which was cleaved upon adamantylamine addition.

• 出版日期2015-3