Aspirin and COX-2 Inhibitor Use in Patients With Stage III Colon Cancer

作者：Ng Kimmie^*; Meyerhardt Jeffrey A; Chan Andrew T; Sato Kaori; Chan Jennifer A; Niedzwiecki Donna; Saltz Leonard B; Mayer Robert J; Benson Al B III; Schaefer Paul L; Whittom Renaud; Hantel Alexander; Goldberg Richard M; Venook Alan P; Ogino Shuji; Giovannucci Edward L; Fuchs Charles S

来源：JNCI-Journal of the National Cancer Institute, 2015, 107(1): dju345.

DOI：10.1093/jnci/dju345

We conducted a prospective, observational study of aspirin and COX-2 inhibitor use and survival in stage III colon cancer patients enrolled in an adjuvant chemotherapy trial. Among 799 eligible patients, aspirin use was associated with improved recurrence-free survival (RFS) (multivariable hazard ratio [HR] = 0.51, 95% confidence interval [CI] = 0.28 to 0.95), disease-free survival (DFS) (HR = 0.68, 95% CI = 0.42 to 1.11), and overall survival (OS) (HR = 0.63, 95% CI = 0.35 to 1.12). Adjusted HRs for DFS and OS censored at five years (in an attempt to minimize misclassification from noncancer death) were 0.61 (95% CI = 0.36 to 1.04) and 0.48 (95% CI = 0.23 to 0.99). Among 843 eligible patients, those who used COX-2 inhibitors had multivariable HRs for RFS, DFS, and OS of 0.53 (95% CI = 0.27 to 1.04), 0.60 (95% CI = 0.33 to 1.08), and 0.50 (95% CI = 0.23 to 1.07), and HRs of 0.47 (95% CI = 0.24 to 0.91) and 0.26 (95% CI = 0.08 to 0.81) for DFS and OS censored at five years. Aspirin and COX-2 inhibitor use may be associated with improved outcomes in stage III colon cancer patients.

• 出版日期2015-1
• 单位西北大学