A FACILE AND CONVENIENT METHOD FOR THE SYNTHESIS OF 6,8-BIS(TRIFLUOROACETYL)QUINOLIN-5-AMINES

作者：Shibata Dai^*; Medebielle Maurice; Hatakenaka Mizuki; Okada Etsuji

来源：Heterocycles, 2012, 84(2): 1277-1284.

DOI：10.3987/COM-11-S(P)38

• Quinolin-5-amine
• Fluorine-Containing Heterocycle
• Aromatic Nucleophilic Substitution
• Amine
• Trifluoroacetyl Group

New 6,8-bis(trifluoroacetyl)quinolin-5-amines (6) were easily prepared in moderate to high yields by the aromatic nucleophilic nitrogen-nitrogen exchange reaction of N,N-dimethyl-6,8-bis(trifluoroacetyl)-quinolin-5-amine (5) with various aliphatic and aromatic amines.

• 出版日期2012-1-1