Adjuvant Chemotherapy for Soft Tissue Sarcomas

作者：Ravi Vinod^*; Patel Shreyaskumar

来源：Surgical Oncology Clinics of North America, 2012, 21(2): 243-+.

DOI：10.1016/j.soc.2011.12.006

• Soft tissue sarcomas
• Adjuvant chemotherapy
• Neoadjuvant chemotherapy
• Mesenchymal neoplasms

Soft tissue sarcomas are rare mesenchymal neoplasms with considerable heterogeneity in biologic behavior and response to systemic therapy. Most patients present with localized disease and are potentially curable with multidisciplinary treatment. In patients with a high risk of developing metastatic disease, optimal use of neoadjuvant/adjuvant therapy has a definite role in improving patient outcomes by decreasing local and distant recurrences. Histology-specific clinical trials enrolling a homogenous high-risk population have been more successful in demonstrating benefit than larger trials with unselected heterogeneous patient populations. In specific histologic subtypes responsive to chemotherapy, neoadjuvant chemotherapy with close monitoring of response is recommended.

• 出版日期2012-4