A one-step synthesized acridine-based fluorescent chemosensor for selective detection of copper(II) ions and living cell imaging

作者：Dai, Qiuzi; Liu, Haiyang; Gao, Chunmei; Li, Wenlu; Zhu, Caizhen; Lin, Chengdong; Tan, Ying; Yuan, Zigao^*; Jiang, Yuyang^*

来源：New Journal of Chemistry, 2018, 42(1): 613-618.

DOI：10.1039/c7nj03615a

• TOPOISOMERASE-II INHIBITORS
• DNA-BINDING LIGANDS
• AQUEOUS-SOLUTION
• AZAACRIDINE DERIVATIVES
• SEQUENTIAL RECOGNITION
• ANTITUMOR TREATMENT
• KINASE INHIBITORS
• HYDROGEN-SULFIDE
• CU2+
• PROBE

Herein, the easily approachable N,N'-(acridine-3,6-diyl)dipicolinamide (ACC) prepared by only one step was evaluated as an efficient and selective chemosensor for the selective detection of copper ions (Cu2+). The fluorescence sensing behavior of ACC toward metal cations was investigated in an HEPES buffer aqueous solution. The fluorescence emission was significantly quenched in the presence of Cu2+ cations, whereas other metal cations showed a low interference. The limit of detection was found to be 1.2 x 10(-7) M. The recognizing mechanism of ACC towards Cu2+ has been investigated by H-1 NMR, HR-MS analysis, and density functional theory (DFT) calculations. Moreover, this sensor was verified to have low cytotoxicity and good imaging characteristics for Cu2+ in living cells; this suggested that ACC was a potential probe for the detection of Cu2+ in vivo.

• 出版日期2018-1-7
• 单位清华大学; 深圳大学