A Synthesis of the Pseudopterosin A-F Aglycone

作者：Cooksey John P^*; Kocienski Philip J; Schmidt Arndt W; Snaddon Thomas N; Kilner Colin A

来源：Synthesis, 2012, 44(17): 2779-2785.

DOI：10.1055/s-0032-1316643

• total synthesis
• terpenoids
• ring closure
• rearrangement
• metathesis
• pericyclic reaction

The synthesis of the pseudopterosin A-F aglycone from 3-methylcatechol features (a) the use of asymmetric Ireland-Claisen and aryl Claisen rearrangements to install three of the four stereocentres present in the molecule and (b) an A--%26gt;AB--%26gt;ABC annulation strategy using ring-closing metathesis and cationic cyclisation reactions as the key steps.

• 出版日期2012-9