Association of polymorphisms in glutathione-S-Transferase and DNA repair genes with ovarian cancer risk in the Russian population

作者：Khokhrin D V^*; Khrunin A V; Moiseev A A; Gorbunova V A; Limborska S A

来源：Russian Journal of Genetics, 2012, 48(7): 764-766.

DOI：10.1134/S1022795412050110

Polymorphism of glutathione-S-transferase (GSTA1, GSTM1, GSTM3, GSTP1, and GSTT1) and DNA repair (ERCC1, ERCC2, and XRCC1) genes in samples of ovarian cancer patients and healthy women of the Russian ethnic group was studied. A trend in the allele frequency variation of ERCC2 gene single nucleotide polymorphism (rs13181, A > C) was revealed. The A allele frequency was higher in the sample of patients (60,6% versus 52,9%, P = 0.058).

• 出版日期2012-7