Accelerated biological ageing in HIV-infected individuals in South Africa: a case-control study

作者:Pathai Sophia*; Lawn Stephen D; Gilbert Clare E; McGuinness Dagmara; McGlynn Liane; Weiss Helen A; Port Jennifer; Christ Theresa; Barclay Karen; Wood Robin; Bekker Linda Gail; Shiels Paul G
来源:AIDS, 2013, 27(15): 2375-2384.
DOI:10.1097/QAD.0b013e328363bf7f

摘要

Objectives:Little is known about the impact of HIV infection on biological ageing in sub-Saharan Africa. The study aimed to assess biological ageing in South African HIV-infected adults and HIV-seronegative individuals using two validated biomarkers, telomere length and CDKN2A expression (a mediator of cellular senescence).Design:A case-control study.Methods:Two hundred and thirty-six HIV-infected adults aged at least 30 years and 250 age and sex frequency matched HIV-seronegative individuals were recruited from clinics in township communities in Cape Town. Biological ageing was evaluated by measurement of telomere length and CDKN2A expression in peripheral blood leukocytes.Results:The median ages of the HIV-infected and HIV-seronegative participants were 39 and 40 years, respectively. Among HIV-infected participants, 87.1% were receiving antiretroviral therapy (ART), their median CD4(+) cell count was 468cells/l and 84.3% had undetectable viral load. Both biomarkers were validated against chronological age in HIV-seronegative individuals. Telomere length was significantly shorter in HIV-infected individuals than in HIV-seronegative individuals (mean relative T/S ratio SE:0.91 +/- 0.007 vs. 1.07 +/- 0.008, P%26lt;0.0001). CD2NKA expression was higher in HIV-infected participants than in HIV-seronegative individuals (mean expression: 0.45 +/- 0.02 vs. 0.36 +/- 0.03, P=0.003). Socioeconomic factors were not associated with biological ageing in HIV-infected participants. However, in participants on ART with undetectable viral load, biomarker levels indicated greater biological ageing in those with lower current CD4(+) cell counts.Conclusion:Telomere length and CDKN2A expression were both consistent with increased biological ageing in HIV-infected individuals. Prospective studies of the impact of HIV on biological ageing in sub-Saharan Africa are warranted.

  • 出版日期2013-9-24