Antimicrobial Susceptibility of Mycoplasma pneumoniae Isolates and Molecular Analysis of Macrolide-Resistant Strains from Shanghai, China

作者：Liu, Yang; Ye, Xinyu; Zhang, Hong; Xu, Xiaogang; Li, Wanhua; Zhu, Demei; Wang, Minggui^*

来源：Antimicrobial Agents and Chemotherapy, 2009, 53(5): 2160-2162.

DOI：10.1128/AAC.01684-08

• COMMUNITY-ACQUIRED PNEUMONIA
• 23S RIBOSOMAL-RNA
• PEDIATRIC-PATIENTS
• IN-VITRO
• INFECTIONS
• GENE
• PCR

Fifty-three Mycoplasma pneumoniae strains were isolated from pediatric patients in Shanghai, China, from October 2005 to February 2008. Of 53 clinical isolates, 44 (83%) were resistant to erythromycin (MICs of > 128 mu g/ml for all 44 strains), azithromycin, and clarithromycin. All macrolide-resistant M. pneumoniae strains harbored an A-to-G transition mutation at position 2063 in 23S rRNA genes. Forty-five (85%) clinical isolates were classified into the P1 gene restriction fragment length polymorphism type I, and six (11%) were type II.

• 出版日期2009-5-1
• 单位上海交通大学; 复旦大学