Marked underdiagnosis and undertreatment of hypertension and hypercholesterolaemia in rheumatoid arthritis

作者：van Breukelen van der Stoep Deborah F^*; van Zeben Derkjen; Klop Boudewijn; van de Geijn Gert Jan M; Janssen Hans J W; van der Meulen Noelle; De Vries Marijke A; Hazes Mieke; Birnie Erwin; Cabezas Manuel Castro

来源：Rheumatology, 2016, 55(7): 1210-1216.

DOI：10.1093/rheumatology/kew039

• cardiovascular risk
• rheumatoid arthritis
• risk assessment

Objective. To investigate the prevalence of underdiagnosis and undertreatment of traditional cardiovascular risk factors in RA patients.
Methods. RA patients a (c) 1/270 years of age without cardiovascular disease (CVD) or diabetes mellitus were included. Systolic blood pressure and a fasting lipid profile were measured. The 10-year CVD risk was estimated using the Dutch Cardiovascular Risk Management (CVRM) guideline and EULAR modifications of the Systemic Coronary Risk Evaluation tables.
Results. A total of 327 patients were included (female gender: 68%). The mean age was 53 (11) years [mean (s.d.)]. The median disease duration was 7 years (inter quartile range: 2-14 years). According to the CVRM guideline, 52% of the patients had a CVD risk a (c) 3/420% and according to the EULAR guidelines, 18% of the patients had a CVD risk a parts per thousand yen 20%. Low-density lipoprotein cholesterol (LDL-C) > 2.5 mmol/l was found in > 80% of the patients with a CVD risk a (c) 3/410% as estimated by both the CVRM and EULAR guidelines, and 32-42% of the patients with a CVD risk a (c) 3/410% had a systolic blood pressure > 140 mmHg, depending on the risk model used. Statins were used in 6% and antihypertensives in 23-25%, and 50-86% of these patients did not reach the recommended treatment targets.
Conclusion. Regardless of the adapted risk assessment model used, untreated hypertension and hypercholesterolaemia were frequently found in RA patients with increased CVD risk. Treatment of these cardiovascular risk factors deserves more attention in RA.

• 出版日期2016-7