A novel method of synthesis of certain indole-3-aldehydes and their thiosemicarbazones as potential anticancer drugs

作者：P V S Naidu; Prakash MMS Kinthada; Y L N Murthy

来源：International Journal of Pharmacy and Biomedical Sciences, 2011.

• Anxiolytic
• Crataegusoxycantha
• Elevated plus maze
• Light dark test
• Actophotometer
• GABA

Indole and its heterocyclic fused derivatives are found to be a potential anticancer, antitumor and antioxidant intermediates. In view of this, it was considered worthwhile; to synthesize Thiazole substituted Indole derivatives as potentially biologically active molecules. In our present work, simple and substituted Indole (1) on Vilsmeier-Haack formylation gave Indole-3-aldehyde(2). Treatment of (2) with thiosemicarbazide in refluxing methanol containing acetic acid gave indole-3-aldehyde thiosemicarbozone with a view of synthesizing their transtinal metal complexes with platinum (Pt), Palladium (Pd), Gold (Au) and Ruthenium (Ru). The precursors, the derivatives/Analogues and the transitional metal complexes of Indole derivatives are excellent candidates as anticancer drugs.

• 出版日期2011