Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines

作者：Llona Minguez Sabin^*; Haggblad Maria; Martens Ulf; Throup Adam; Loseva Olga; Jemth Ann Sofie; Lundgren Bo; Scobie Martin; Helleday Thomas^*

来源：Bioorganic & Medicinal Chemistry Letters, 2017, 27(16): 3897-3904.

DOI：10.1016/j.bmc1.2017.06.038

A high-throughput screening campaign using a commercial compound library (ChemBridge DiverSET) revealed diverse chemotypes as inhibitors of the human dCTP pyrophosphatase 1 (dCTPase). Triazole, triazolopyrimidine, triazinoindole, quinoline hydrazone and arylpiperazine hits were clustered, confirmed by IC50 determinations, and their preliminary structure-activity-relationships (SAR) and ligand efficiency scores are discussed in this letter.

• 出版日期2017-8-15