A comparative synthesis of 6-benzyl-2,3-dihydroimidazo[2,1-a]phthalazine and 2H-7-benzyl-3,4-dihydropyrimido[2,1-a]phthalazine

作者：Munin Javier; Santana Lourdes; Uriarte Eugenio; Borges Fernanda; Quezada Elias^*

来源：Tetrahedron Letters, 2015, 56(6): 828-830.

DOI：10.1016/j.tetlet.2014.12.121

• Synthesis
• Imidazophthalazine
• Pyrimidophthalazine
• Cyclization
• Condensation

Two new synthetic strategies have been developed for the synthesis of a new class of cyclophthalazine derivatives. 6-BenzyL-2,3-dihydroimidazo[2,1-a]phthalazine and 2H-7-benzyl-3,4-dihydropyrimido[2,1-a]phthalazine were obtained (i) by intramolecular cyclization of the 2-(aminoalkyl)-4-benzyl-2H-phthalazin-1-one or (ii) by intramolecular cyclization of the corresponding 2-(4-benzylphthalazin-1(2H)-ylide-neamino)alcohols previously prepared. The second of the described routes afforded the desired derivatives in high yields.

• 出版日期2015-2-4